http://www.wikio.com/search=Arthur Powell Wikio - Arthur Powell http://www.wikio.com/search/Arthur+Powell?rinfoid=62740990 By David Lambert - The turning points in the careers of nine historical Edwardian figures are explored in this 8-part series The Edwardians, which was produced in 1972 by the BBC and partially aired in... (more) Wed, 02 Jul 2008 12:21:00 GMT http://www.wikio.com/search/Arthur+Powell?rinfoid=62740990 2008-07-02T12:21:00Z http://www.wikio.com/search/Arthur+Powell?rinfoid=62381489 PwC, the professional services group, must become more agile if it wants to maintain and improve on its market-leading position, according to its new head, Ian Powell, who takes over on Tuesday Sun, 29 Jun 2008 17:24:00 GMT http://www.wikio.com/search/Arthur+Powell?rinfoid=62381489 2008-06-29T17:24:00Z http://www.wikio.com/search/Arthur+Powell?rinfoid=61539871 The transcription factor IRF4 (interferon regulatory factor 4) is required during an immune response for lymphocyte activation and the generation of immunoglobulin-secreting plasma cells. Multiple myeloma, a malignancy of plasma cells, has a complex molecular aetiology with several subgroups defined by gene expression profiling and recurrent chromosomal translocations. Moreover, the malignant clone can sustain multiple oncogenic lesions, accumulating genetic damage as the disease progresses. Current therapies for myeloma can extend survival but are not curative. Hence, new therapeutic strategies are needed that target molecular pathways shared by all subtypes of myeloma. Here we show, using a loss-of-function, RNA-interference-based genetic screen, that IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism. Gene expression profiling and genome-wide chromatin immunoprecipitation analysis uncovered an extensive network of IRF4 target genes and identified MYC as a direct target of IRF4 in activated B cells and myeloma. Unexpectedly, IRF4 was itself a direct target of MYC transactivation, generating an autoregulatory circuit in myeloma cells. Although IRF4 is not genetically altered in most myelomas, they are nonetheless addicted to an aberrant IRF4 regulatory network that fuses the gene expression programmes of normal plasma cells and activated B cells. Sun, 22 Jun 2008 00:00:00 GMT http://www.wikio.com/search/Arthur+Powell?rinfoid=61539871 2008-06-22T00:00:00Z http://www.wikio.com/search/Arthur+Powell?rinfoid=61411764 AMIR KHAN has vowed to put on a punch perfect display against Michael Gomez tonight to reinforce his world title claims. Sat, 21 Jun 2008 00:16:56 GMT http://www.wikio.com/search/Arthur+Powell?rinfoid=61411764 2008-06-21T00:16:56Z http://www.wikio.com/search/Arthur+Powell?rinfoid=61412046 AMIR Khan believes being pushed to the brink of collapse as part of his gruelling new training programme has made him a fitter fighter than ever as he prepares to face Michael Sat, 21 Jun 2008 00:00:00 GMT http://www.wikio.com/search/Arthur+Powell?rinfoid=61412046 2008-06-21T00:00:00Z http://www.wikio.com/search/Arthur+Powell?rinfoid=61364790 AMIR Khan believes being pushed to the brink of collapse as part of his gruelling new training programme has made him a fitter fighter than ever as he prepares to face Michael Gomez in Birmingham. Fri, 20 Jun 2008 16:26:52 GMT http://www.wikio.com/search/Arthur+Powell?rinfoid=61364790 2008-06-20T16:26:52Z http://www.wikio.com/search/Arthur+Powell?rinfoid=61239716 AMIR Khan branded Michael Gomez an "idiot" and accused him of running scared after the Manchester fighter failed to show up for a Press conference ahead of Saturday's Commonwealth title fight in Birmingham. Thu, 19 Jun 2008 17:00:45 GMT http://www.wikio.com/search/Arthur+Powell?rinfoid=61239716 2008-06-19T17:00:45Z http://www.wikio.com/search/Arthur+Powell?rinfoid=61136973 AMIR Khan branded Michael Gomez an "idiot" and accused him of running scared after the Manchester fighter failed to show up for a press conference ahead of Saturday&#3 Wed, 18 Jun 2008 23:19:43 GMT http://www.wikio.com/search/Arthur+Powell?rinfoid=61136973 2008-06-18T23:19:43Z http://www.wikio.com/search/Arthur+Powell?rinfoid=61099872 AMIR Khan branded Michael Gomez an "idiot" and accused him of running scared after the Manchester fighter failed to show up for a press conference ahead of Saturday's Commonwealth title fight in Birmingham. Wed, 18 Jun 2008 17:25:28 GMT http://www.wikio.com/search/Arthur+Powell?rinfoid=61099872 2008-06-18T17:25:28Z http://www.wikio.com/search/Arthur+Powell?rinfoid=60451420 L-R: Make up artist Bud Westmore with stars Ann Blyth and William Powell on the set of Mr. Peabody and The Mermaid (1948). Click photo to enlarge. "Arthur Peabody (William Powell) is a slightly stuffy businessman from Boston who after turning fifty finds himself suffering from a full-fledged midlife crisis. On the advice of his doctor, Peabody and his wife Polly (Irene Hervey) head to the Caribbean for a restful vacation. One evening, Peabody decides to do some fishing, and... Fri, 13 Jun 2008 07:01:00 GMT http://www.wikio.com/search/Arthur+Powell?rinfoid=60451420 2008-06-13T07:01:00Z